Antibody derived from insect glycosaminoglycan

Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs

Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identified, and characterised, a novel marine polysaccharide with the potential to be ...

Insect-derived chitinases.

Insect chitinases belong to family 18 of the glycoside hydrolase superfamily (GH18) and comprise endo-splitting enzymes that retain the anomeric β-(1,4) configuration of the cleavage products. However, some of them have lost their catalytic activity but retained the chitin binding activity and/or possess imaginal disc growth factor activity. In all sequenced insect genomes, multiple genes encod...

Food Derived from Insect-protected Corn Line Mon

Capillary electrophoresis for the analysis of glycosaminoglycan-derived disaccharides.

Capillary electrophoresis is a common technique used for glycosaminoglycan-derived disaccharide analysis because of its high resolving power, high separation efficiency, high sensitivity, short analysis time, and straightforward operation. CE coupled to laser-induced fluorescence (LIF) detection shows an approximately 100 times higher sensitivity than traditional UV detection at 232 nm. 2-Amino...

Recombination of univalent subunits derived from rabbit antibody.

The reaction of papain with rabbit antibody has been shown by Porter (1,2) to result in the release of three nonprecipitating fragments, two of which have the capacity to inhibit the reaction of the same untreated antibody with homologous antigen. These active fragments have molecular weights of 50,000 and 53,000 (3). Their combining sites have been found to be essentially intact (4, 5), and me...